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IL-8是濕疹關鍵致病因子　

在濕疹的各階段均有不同程度的增高

◎ IL-8在手臂、頸、背部的濕疹病灶處均有增高

◎ IL-8含量與紅斑、水腫/丘疹、瘙癢等癥狀的嚴重程度成正相關

恩博克作用機理　

◎ 恩博克是中和IL-8的單抗藥物，其靶點是濕疹病灶區(qū)中增高的IL-8

◎ 恩博克僅阻斷表皮中增高的IL-8，不影響體內(nèi)IL-8的正常生理功能

參考文獻：

l Tseveendorj Amarbayasgalan, Hitoshi Takahashi, Itaru Dekio, Eishin Morita. Interleukin-8 content in the stratum corneum as an indicator of the severity of inflammation in the lesions of atopic dermatitis. Int Arch Allergy Immunol 2013; 160: 63–74.

l Chizuko Koga , Kenji Kabashima , Noriko Shiraishi ,etc. Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol. 2008 Nov; 128(11): 2625-2630.

l A Genovese, A Detoraki, F Granata, etc. Angiogenesis, lymphangiogenesis and atopic dermatitis. Chem Immunol Allergy. 2012; 96:50-60.