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IL-8 是銀屑病的直接致炎因子

◎ IL-8是IL-23、IL-17的下游細(xì)胞因子，IL-17刺激表皮角質(zhì)細(xì)胞產(chǎn)生大量趨化因子IL-8

◎ IL-8在銀屑病皮損區(qū)含量是正常皮膚的83.3倍

IL-8參與銀屑病的三大病理反應(yīng)

◎ 高濃度的IL-8趨化大量中性粒細(xì)胞和部分T淋巴細(xì)胞浸潤(rùn)到積聚區(qū)，形成炎性微膿腫

◎ IL-8在積聚區(qū)促進(jìn)角質(zhì)細(xì)胞的過度增生

◎ IL-8導(dǎo)致真皮層毛細(xì)血管的大量增生

恩博克作用機(jī)理

◎ 抑制角質(zhì)細(xì)胞過度增生，控制鱗屑產(chǎn)生

◎ 抑制中性粒細(xì)胞組織浸潤(rùn)，控制局部炎癥反應(yīng)

◎ 抑制毛細(xì)血管增生，延緩銀屑病復(fù)發(fā)

參考文獻(xiàn)：

l Frank O Nestle , Daniel H Kaplan, Jonathan Barker. Psoriasis. N Engl J Med 2009; 361:496-509.

l Chizuko Koga , Kenji Kabashima , etc. Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol. 2008 Nov; 128(11):2625-2630.

l Hideaki Watanabe , Mio Kawaguchi, etc. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. J Invest Dermatol. 2009 Mar; 129(3):650-6.

l Jaymie Baliwag , Drew H Barnes , Andrew Johnston . Cytokines in psoriasis. Cytokine. 2015 June; 73(2): 342–350.

l Remo C Russo , Cristiana C Garcia, Mauro M Teixeira, Flavio A Amaral. The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases. Expert Rev Clin Immunol. 2014 May; 10(5):593-619.

l A Tuschil , C Lam, A Haslberger, I Lindley. Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation. J Invest Dermatol. 1992 Sep; 99(3):294-8.